pI: 5.8883 |
Length (AA): 855 |
MW (Da): 98131 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
158 | 264 | 4tx5 (A) | 56 | 161 | 10.00 | 0 | 0 | 0.239346 | -0.55 |
158 | 242 | 5lpn (B) | 925 | 1007 | 13.00 | 0 | 0 | 0.301015 | -1.27 |
158 | 239 | 4o9b (A) | 255 | 335 | 21.00 | 0 | 0 | 0.382506 | -1.2 |
158 | 312 | 5cwp (A) | 9 | 162 | 12.00 | 0 | 0.01 | 0.321387 | -0.57 |
189 | 414 | 3cbp (A) | 125 | 312 | 29.00 | 0.72 | 0.04 | -0.0302725 | 2.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128175)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G17690 | hypothetical protein |
Babesia bovis | BBOV_IV006620 | conserved hypothetical protein |
Brugia malayi | Bm1_23940 | Hypothetical 84.0 kDa protein in SGA1-KTR7 intergenic region |
Candida albicans | CaO19.9407 | similar to S. cerevisiae YIL091C |
Candida albicans | CaO19.1849 | similar to S. cerevisiae YIL091C |
Caenorhabditis elegans | CELE_Y41C4A.9 | Protein Y41C4A.9 |
Cryptosporidium hominis | Chro.70038 | hypothetical protein |
Cryptosporidium parvum | cgd7_250 | conserved protein |
Dictyostelium discoideum | DDB_G0289235 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3735 | CG3735 gene product from transcript CG3735-RB |
Echinococcus granulosus | EgrG_000837700 | digestive organ expansion factor |
Entamoeba histolytica | EHI_177370 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000837700 | digestive organ expansion factor |
Giardia lamblia | GL50803_6211 | Protein required for cell viability |
Homo sapiens | ENSG00000117597 | digestive organ expansion factor homolog (zebrafish) |
Leishmania braziliensis | LbrM.14.0420 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_140420.1 | Protein of unknown function (DUF1253), putative |
Leishmania infantum | LinJ.14.0420 | hypothetical protein, conserved |
Leishmania major | LmjF.14.0410 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.0410 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04023 | hypothetical protein |
Mus musculus | ENSMUSG00000016181 | digestive organ expansion factor homolog (zebrafish) |
Neospora caninum | NCLIV_035820 | hypothetical protein |
Oryza sativa | 4338320 | Os05g0295100 |
Onchocerca volvulus | OVOC7530 | Digestive organ expansion factor homolog |
Plasmodium berghei | PBANKA_1203400 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium falciparum | PF3D7_1005100 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium knowlesi | PKNH_0803800 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium vivax | PVX_094450 | hypothetical protein, conserved |
Plasmodium yoelii | PY02979 | Drosophila melanogaster CG3735 gene product |
Saccharomyces cerevisiae | YIL091C | Utp25p |
Schistosoma japonicum | Sjp_0207720 | Digestive organ expansion factor homolog, putative |
Schistosoma japonicum | Sjp_0312610 | Digestive organ expansion factor homolog, putative |
Schistosoma mansoni | Smp_158840 | hypothetical protein |
Schmidtea mediterranea | mk4.000072.02 | Digestive organ expansion factor homolog |
Trypanosoma brucei gambiense | Tbg972.7.4900 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.4340 | Protein of unknown function (DUF1253), putative |
Trypanosoma congolense | TcIL3000_7_3530 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508857.100 | Protein of unknown function (DUF1253), putative |
Trypanosoma cruzi | TcCLB.504213.20 | Protein of unknown function (DUF1253), putative |
Toxoplasma gondii | TGME49_270960 | hypothetical protein |
Theileria parva | TP01_1213 | hypothetical protein |
Trichomonas vaginalis | TVAG_075430 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4340 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4340 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4340 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.4340 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y41C4A.9 | Caenorhabditis elegans | slow growth | wormbase |
YIL091C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_270960 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.